Part 3: Coffee & Psilocybin: Microdosing, Macrodosing & Neurochemistry

coffee-and-psilocybin-microdosing-macrodosing-neurochemistry

Can you mix coffee with psilocybin? Studies suggest caffeine and psilocybin act on overlapping serotonin and dopamine pathways but with opposite energetic profiles. Here’s how timing, dosage, and neurochemistry determine whether the combo enhances focus or increases anxiety. (Not medical advice.)

Part 2: Coffee + Ayahuasca: Timing, Risks & Guidelines

Coffee & Ayahuasca timing, risks, guidelines

Can you drink coffee before or after an ayahuasca ceremony? Science shows caffeine mildly inhibits MAO enzymes, while ayahuasca’s β-carbolines strongly block MAO-A. Combining them may elevate blood pressure, heart rate, and anxiety. Here’s what the research says—and how to time caffeine safely. (Not medical advice.)

Part 1: Coffee & Psychedelics: What Science Actually Says

Coffee & Ayahuasca

Can coffee mix safely with psychedelics? Published research on caffeine, ayahuasca, and psilocybin suggests caution. Coffee mildly inhibits MAO enzymes and raises blood pressure. Ayahuasca temporarily blocks MAO-A. Psilocybin alters serotonin signaling. Here’s what science—and only science—currently shows. (Not medical advice.)