Part 2: Coffee + Ayahuasca: Timing, Risks & Guidelines

Coffee & Ayahuasca timing, risks, guidelines

Can you drink coffee before or after an ayahuasca ceremony? Science shows caffeine mildly inhibits MAO enzymes, while ayahuasca’s β-carbolines strongly block MAO-A. Combining them may elevate blood pressure, heart rate, and anxiety. Here’s what the research says—and how to time caffeine safely. (Not medical advice.)